The omega-3 and Nano-curcumin effects on vascular cell adhesion molecule (VCAM) in episodic migraine patients: a randomized clinical trial

Abstract Objective The purpose of this clinical trial was to examine the effect omega-3 fatty acids (W-3 FAs), nanocurcumin and their combination on serum levels gene expression VCAM in patients with episodic migraine. Results In study, 80 were randomly divided 4 groups receive for 2 months. Both showed remarkable decreases after single W-3 combined interventions. However, a borderline significant change no observed supplementation control group, respectively. While difference between study concentrations existed, there meaningful among groups. It appears that can relieve level its Moreover, might cause more declines migraine than when is administered alone. Trial Registration : This registered Iranian Registry Clinical Trials (IRCT) ID number: NCT02532023.